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Risperidone Provides Better Improvement of Sleep Disturbances Than Haloperidol Therapy in Schizophrenia Patients With Cannabis-Positive Urinalysis

Thomas-Brown, Peta-Gaye L and Martin, Jacqueline S and Sewell, Clayton A and Abel, Wendel D and Gossell-Williams, Maxine D

Frontiers in pharmacology

2018

9

Cannabis ; Actigraphy ; Haloperidol ; Risperidone ; Schizophrenia ; Sleep

769

A high percentage of persons with Schizophrenia also uses and this may potentially alter the therapeutic benefits of the antipsychotic medications prescribed. The aim of this study was to assess the impact of usage on antipsychotic therapy of sleep disturbances in schizophrenia subjects. Male subjects, ?18 years, admitted to the University Hospital of the West Indies psychiatric ward between October 2015 and October 2016, and diagnosed with schizophrenia were recruited for the study. Following written informed consent to the study, subjects were prescribed either risperidone monotherapy or haloperidol monotherapy orally for 14 days and classified as users (CU) or non-users (non-CU), with presence/absence of metabolite in urine samples. After 1 week of admission, subjects wore the Actiwatch-2 device, to record sleep data for 7 consecutive nights. Inferential statistical analysis involved non-parametric tests, expressed as median and inter-quartile ranges (IQR), with <0.05 considered...

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